Check Closely (two)pentobarbital will lower the extent or outcome of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Strong CYP3A4 inducers may possibly reduce suvorexant efficacy; if amplified suvorexant dose demanded, usually do not exceed 20 mg/dayRight after stopping a CYP3A4 inducer, as the effects with … Read More